Two new studies published in the March issue of Oral Diseases have indicated that volatile organic compounds associated with oral malodour are products of oxidative stress, generated by lipid peroxidation of polyunsaturated fatty acids in cell membranes. The first paper published by Phillips et al states that Increased oxidative stress in the oral cavity of patients with oral malodour may account for the increased risk of atherosclerosis, coronary heart disease and stroke associated with periodontal disease.

Further study carried out by Yaegaki, Qian, Lee et al has suggested that volatile sulphur compounds (VSCs) such as hydrogen sulfide, inhibits super oxide dismutase (SOD )activity, a major endogenous antioxidant enzyme . The study also goes on to suggest that VSCs can cause oxidative damage. The authors concluded that SOD is the body's major defence against oxidative damage. Cu,Zn- and Mn-SOD, and human gingival fibroblast (HGF) SOD activities were strongly inhibited by hydrogen sulfide. The inhibition of SOD resulted in oxidative damage and apoptosis.

Oral Diseases : Volume 11 Issue s1 Page 104 - March 2005 and Volume 11 Issue s1 Page 32 - March 2005